The aim of a study was to characterize the maternal glycemic response to Betamethasone in subjects without diabetes compared to subjects with diabetes.
Blood glucose levels in 22 gravidae without diabetes and 11 gravidae with diabetes were recorded for 48h following Betamethasone administration for threatened preterm delivery.
All subjects with diabetes and the majority of those without diabetes had significant hyperglycemia during the study period.
Mean maximum blood glucose was higher for those with diabetes ( 205mg/dL versus 173mg/dL, p less than 0.01 ).
Mean time to reach the maximum glucose level was similar for both groups.
Result of a glucose tolerance test given immediately prior to Betamethasone correlated strongly with amount of time spent with hyperglycemia for subjects without diabetes ( rho=0.59, p less than 0.01 ).
Morbidly obese subjects spent less time with hyperglycemia than those with lower body mass indices ( p=0.03 ).
In conclusion, both subjects with and without diabetes have demonstrated significant hyperglycemia after receipt of antenatal Betamethasone. ( Xagena )
Jolley JA et al, Diabetes Res Clin Pract 2016;118: 98-104